InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atxn1

Summary

InnateDB Protein

IDBP-148227.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atxn1

Protein Name

ataxin 1

Synonyms

2900016G23Rik; Atx1; C85907; ENSMUSG00000074917; Gm10786; Sca1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089217

InnateDB Gene

IDBG-148225 (Atxn1)

Protein Structure

UniProt Annotation

Function

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (By similarity). May be involved in RNA metabolism. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269PubMed:9778246}. Note=Colocalizes with USP7 in the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. In brain, the pattern of distribution is limited to neuron populations.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 234 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	234 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008266	poly(U) RNA binding
GO:0034046	poly(G) binding
GO:0043621	protein self-association

Biological Process

GO:0006351	transcription, DNA-templated
GO:0008344	adult locomotory behavior
GO:0008542	visual learning
GO:0042326	negative regulation of phosphorylation
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051168	nuclear export
GO:0060079	regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016363	nuclear matrix
GO:0042272	nuclear RNA export factor complex
GO:0042405	nuclear inclusion body