InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAMTS12

Summary

InnateDB Protein

IDBP-14833.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS12

Protein Name

ADAM metallopeptidase with thrombospondin type 1 motif, 12

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000344847

InnateDB Gene

IDBG-14831 (ADAMTS12)

Protein Structure

UniProt Annotation

Function

Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. {ECO:0000269PubMed:16611630, ECO:0000269PubMed:17895370, ECO:0000269PubMed:18485748}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle and fat. Detected at significant levels in fetal lung. Widely expressed in gastric carcinomas and in cancer cells of diverse origin. {ECO:0000269PubMed:11279086, ECO:0000269PubMed:16611630}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007160	cell-matrix adhesion
GO:0016477	cell migration
GO:0030167	proteoglycan catabolic process
GO:0032331	negative regulation of chondrocyte differentiation
GO:0050727	regulation of inflammatory response
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071773	cellular response to BMP stimulus
GO:1901509	regulation of endothelial tube morphogenesis
GO:1902203	negative regulation of hepatocyte growth factor receptor signaling pathway
GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus
GO:2001113	negative regulation of cellular response to hepatocyte growth factor stimulus

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR010294 ADAM-TS Spacer 1
IPR010909 PLAC

PFAM

PF00090
PF01421
PF01562
PF05986
PF08686

PRINTS

PIRSF

SMART

SM00209

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P58397