InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il1rl2

Summary

InnateDB Protein

IDBP-148346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il1rl2

Protein Name

interleukin 1 receptor-like 2

Synonyms

AI481289; AW551444; IL-1Rrp2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092630

InnateDB Gene

IDBG-148344 (Il1rl2)

Protein Structure

UniProt Annotation

Function

Receptor for the interleukin IL36G. Binding to the agonist leads to the activation of NF-kappa-B (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0004909	interleukin-1, Type I, activating receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0032755	positive regulation of interleukin-6 production
GO:0045087	innate immune response (InnateDB)
GO:0045582	positive regulation of T cell differentiation
GO:0050727	regulation of inflammatory response
GO:0070498	interleukin-1-mediated signaling pathway

Cellular Component

GO:0005575	cellular_component
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1913107

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR004074 Interleukin-1 receptor type I/II
IPR004076 Interleukin-1 receptor type 1
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM

PF01582
PF13676
PF07679

PRINTS

PR01536
PR01538

PIRSF

SMART

SM00255
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt