InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp11c

Summary

InnateDB Protein

IDBP-148386.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp11c

Protein Name

ATPase, class VI, type 11C

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099066

InnateDB Gene

IDBG-148380 (Atp11c)

Protein Structure

UniProt Annotation

Function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids. {ECO:0000269PubMed:21423172, ECO:0000269PubMed:21423173, ECO:0000269PubMed:21518881}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in the presence of TMEM30B (By similarity). {ECO:0000250}.

Disease Associations

Note=Mice defective in Atp11c show defective B lymphopoiesis, specifically in mature bone marrow, hyperbilirubinemia linked to mild cholestasis and hepatocelular carcinoma (PubMed:21423173 and PubMed:21518881).

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004012	phospholipid-translocating ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0002329	pre-B cell differentiation
GO:0006812	cation transport
GO:0008152	metabolic process
GO:0015914	phospholipid transport
GO:0045332	phospholipid translocation
GO:0045579	positive regulation of B cell differentiation

Cellular Component

GO:0005765	lysosomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1859661

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR006539 Cation-transporting P-type ATPase, subfamily IV
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QZW0