Version 5.4
Mus musculus Protein: Nacad
Summary
InnateDB Protein IDBP-148397.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nacad
Protein Name NAC alpha domain containing
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000049490
InnateDB Gene IDBG-148395 (Nacad)
Protein Structure
UniProt Annotation
Function May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
GO:0015031 protein transport
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:3603030
InterPro IPR002715 Nascent polypeptide-associated complex NAC domain
PFAM PF01849
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5SWP3
PhosphoSite PhosphoSite-Q5SWP3
TrEMBL
UniProt Splice Variant
Entrez Gene 192950
UniGene Mm.337771
RefSeq NP_001075121
MGI ID
MGI Symbol Nacad
OMIM
CCDS CCDS36108
HPRD
IMGT
EMBL AB182283 AL603787 BC072589
GenPept BAD23961 CAI24213

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca