InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR65

Summary

InnateDB Protein

IDBP-14842.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR65

Protein Name

G protein-coupled receptor 65

Synonyms

hTDAG8; TDAG8;

Species

Homo sapiens

Ensembl Protein

ENSP00000267549

InnateDB Gene

IDBG-14840 (GPR65)

Protein Structure

UniProt Annotation

Function

Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation- induced cell death or differentiation of T-cells. {ECO:0000269PubMed:11309421}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes. {ECO:0000269PubMed:11309421, ECO:0000269PubMed:9655242}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0006915	apoptotic process
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0010447	response to acidity
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031532	actin cytoskeleton reorganization
GO:0032862	activation of Rho GTPase activity
GO:0051496	positive regulation of stress fiber assembly