InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lpxn

Summary

InnateDB Protein

IDBP-148451.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lpxn

Protein Name

leupaxin

Synonyms

4933402K05Rik; A530083L21Rik; AV278559; LDPL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025601

InnateDB Gene

IDBG-148447 (Lpxn)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269PubMed:12674328, ECO:0000269PubMed:17640867, ECO:0000269PubMed:18497331, ECO:0000269PubMed:19917054}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B- cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in osteoclasts (at protein level). Highly expressed in vascular smooth muscle. {ECO:0000269PubMed:12674328, ECO:0000269PubMed:18497331}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007155	cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0050859	negative regulation of B cell receptor signaling pathway

Cellular Component

GO:0002102	podosome
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0042995	cell projection
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:2147677

InterPro

IPR001781 Zinc finger, LIM-type
IPR017305 Transforming growth factor beta-1-induced transcript 1 protein/Leupaxin

PFAM

PF00412

PRINTS

PIRSF

PIRSF037881

SMART

SM00132

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99N69

PhosphoSite

PhosphoSite-Q99N69

TrEMBL

UniProt Splice Variant

Entrez Gene

107321

UniGene

RefSeq

NP_598913

MGI ID

MGI Symbol

Lpxn

OMIM

CCDS

CCDS29638

HPRD

IMGT

EMBL

AB053936 AB071194

GenPept

BAB40667 BAC22615