InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nrbp1

Summary

InnateDB Protein

IDBP-148479.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nrbp1

Protein Name

nuclear receptor binding protein 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031034

InnateDB Gene

IDBG-148477 (Nrbp1)

Protein Structure

UniProt Annotation

Function

May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. {ECO:0000250UniProtKB:Q9UHY1}.

Subcellular Localization

Cytoplasm, cell cortex {ECO:0000269PubMed:12176995}. Endomembrane system {ECO:0000269PubMed:12176995}. Cell projection, lamellipodium {ECO:0000269PubMed:12176995}. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006888	ER to Golgi vesicle-mediated transport

Cellular Component

GO:0005938	cell cortex
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:2183436

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt