Version 5.4
Mus musculus Protein: Dusp4
Summary
InnateDB Protein IDBP-148487.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dusp4
Protein Name dual specificity phosphatase 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000033930
InnateDB Gene IDBG-148485 (Dusp4)
Protein Structure
UniProt Annotation
Function Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0001706 endoderm formation
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2442191
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001763 Rhodanese-like domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00102
PF00782
PF00581
PRINTS PR00700
PR01764
PIRSF PIRSF000939
SMART SM00194
SM00450
SM00404
SM00195
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BFV3
PhosphoSite PhosphoSite-Q8BFV3
TrEMBL
UniProt Splice Variant
Entrez Gene 319520
UniGene Mm.170276
RefSeq NP_795907
MGI ID
MGI Symbol Dusp4
OMIM
CCDS CCDS22241
HPRD
IMGT
EMBL AK053746 AK080964
GenPept BAC35504 BAC38097

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca