InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gdf2

Summary

InnateDB Protein

IDBP-148657.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gdf2

Protein Name

growth differentiation factor 2

Synonyms

Bmp9;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098286

InnateDB Gene

IDBG-148655 (Gdf2)

Protein Structure

UniProt Annotation

Function

Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. {ECO:0000269PubMed:23300529}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0001570	vasculogenesis
GO:0001649	osteoblast differentiation
GO:0001937	negative regulation of endothelial cell proliferation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006006	glucose metabolic process
GO:0006879	cellular iron ion homeostasis
GO:0010596	negative regulation of endothelial cell migration
GO:0010628	positive regulation of gene expression
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030182	neuron differentiation
GO:0030308	negative regulation of cell growth
GO:0030509	BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0032757	positive regulation of interleukin-8 production
GO:0032924	activin receptor signaling pathway
GO:0040007	growth
GO:0045603	positive regulation of endothelial cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048514	blood vessel morphogenesis
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0071773	cellular response to BMP stimulus
GO:2000279	negative regulation of DNA biosynthetic process

Cellular Component

GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1321394

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR00669

PIRSF

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt