InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chn2

Summary

InnateDB Protein

IDBP-148685.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chn2

Protein Name

chimerin (chimaerin) 2

Synonyms

1700026N20Rik; 4930557O16Rik; ARHGAP3; Bch;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066078

InnateDB Gene

IDBG-148681 (Chn2)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for p21-rac. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005622	intracellular
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1917243

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR008936 Rho GTPase activation protein
IPR020454 Diacylglycerol/phorbol-ester binding

PFAM

PF00620
PF00130

PRINTS

PR00008

PIRSF

SMART

SM00324
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt