InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Syngr3

Summary

InnateDB Protein

IDBP-148705.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syngr3

Protein Name

synaptogyrin 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000007236

InnateDB Gene

IDBG-148703 (Syngr3)

Protein Structure

UniProt Annotation

Function

Involved in the positive regulation of dopamine transporter activity. Probably facilitates the physical and functional interactions of the transporter with the dopamine vesicular storage system, allowing a more efficient loading of the vesicles with extracellular dopamine after release. {ECO:0000269PubMed:19357284}.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cell junction, synapse. Note=Found at the neuromuscular synapses.

Disease Associations

Tissue Specificity

Found in the brain across the dorsal and ventral corpus striatum as well as in the cortex. {ECO:0000269PubMed:19357284}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042169	SH2 domain binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0021762	substantia nigra development
GO:0032411	positive regulation of transporter activity

Cellular Component

GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0031594	neuromuscular junction
GO:0045202	synapse