InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gfer

Summary

InnateDB Protein

IDBP-148757.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gfer

Protein Name

growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)

Synonyms

Alr; ERV1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049186

InnateDB Gene

IDBG-148755 (Gfer)

Protein Structure

UniProt Annotation

Function

FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Mitochondrion intermembrane space {ECO:0000250}.

Disease Associations

Tissue Specificity

Preferentially expressed in the liver and in testis. {ECO:0000269PubMed:8900538}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0016972	thiol oxidase activity
GO:0050660	flavin adenine dinucleotide binding