InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pglyrp1

Summary

InnateDB Protein

IDBP-148762.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pglyrp1

Protein Name

peptidoglycan recognition protein 1

Synonyms

Pglyrp; PGRP; PGRP-S; Tag7; Tasg7; Tnfsf3l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032573

InnateDB Gene

IDBG-148760 (Pglyrp1)

Protein Structure

UniProt Annotation

Function

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria. Involved in innate immunity. May function in intracellular killing of bacteria. The soluble form triggers apoptosis in vitro. {ECO:0000269PubMed:12649138, ECO:0000269PubMed:9660837, ECO:0000269PubMed:9707603}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9660837}. Secreted {ECO:0000269PubMed:9660837}. Note=Exists in both soluble and membrane-associated forms.

Disease Associations

Tissue Specificity

Strongly expressed in spleen and lung. Also detected in brain and thymus. In the lung, expressed in the intraalveolar space, in the brain, expressed in the Purkinje cells of the cerebellum and in certain layers of neurons in the hippocampus. Also detected in cells filling the space within the intestinal villus. {ECO:0000269PubMed:9707603}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0008270	zinc ion binding
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity
GO:0016019	peptidoglycan receptor activity
GO:0042834	peptidoglycan binding

Biological Process

GO:0002221	pattern recognition receptor signaling pathway
GO:0006915	apoptotic process
GO:0009253	peptidoglycan catabolic process
GO:0016045	detection of bacterium
GO:0032689	negative regulation of interferon-gamma production
GO:0032827	negative regulation of natural killer cell differentiation involved in immune response
GO:0044117	growth of symbiont in host
GO:0045087	innate immune response (InnateDB)
GO:0050728	negative regulation of inflammatory response
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1345092

InterPro

IPR002502 N-acetylmuramoyl-L-alanine amidase domain
IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
IPR017331 Peptidoglycan recognition protein, PGRP-S

PFAM

PF01510

PRINTS

PIRSF

PIRSF037945

SMART

SM00644
SM00701

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt