Version 5.4
Mus musculus Protein: Pus3
Summary
InnateDB Protein IDBP-148786.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pus3
Protein Name pseudouridine synthase 3
Synonyms 2610020J05Rik; 5730412F04Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000034615
InnateDB Gene IDBG-148784 (Pus3)
Protein Structure
UniProt Annotation
Function Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs. Also acts on position 38, but much less efficiently. {ECO:0000269PubMed:11027153}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0009982 pseudouridine synthase activity
Biological Process
GO:0001522 pseudouridine synthesis
GO:0009451 RNA modification
GO:0031119 tRNA pseudouridine synthesis
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1914299
InterPro IPR001406 Pseudouridine synthase I, TruA
IPR020097 Pseudouridine synthase I, TruA, alpha/beta domain
IPR020103 Pseudouridine synthase, catalytic domain
PFAM PF01416
PRINTS
PIRSF PIRSF001430
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JI38
PhosphoSite PhosphoSite-
TrEMBL Q9CS32
UniProt Splice Variant
Entrez Gene 67049
UniGene Mm.425574
RefSeq NP_075781
MGI ID
MGI Symbol Pus3
OMIM
CCDS CCDS22965
HPRD
IMGT
EMBL AF266505 AK019213 AK079095 BC029253
GenPept AAF91402 AAH29253 BAB31604 BAC37536

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca