InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eri1

Summary

InnateDB Protein

IDBP-148789.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eri1

Protein Name

exoribonuclease 1

Synonyms

3\'hexo; 3110010F15Rik; eri-1; Thex1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033927

InnateDB Gene

IDBG-148787 (Eri1)

Protein Structure

UniProt Annotation

Function

RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Binds with high affinity to the 3' side of the stem-loop structure and to the downstream cleavage product (DCP) of histone pre-mRNAs. Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs (By similarity). Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. {ECO:0000250, ECO:0000269PubMed:18438418}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18438418}. Nucleus {ECO:0000269PubMed:18438418}. Nucleus, nucleolus {ECO:0000269PubMed:18438418}.

Disease Associations

Tissue Specificity

Widely expressed with high levels in spleen, thymus and testis (at protein level). {ECO:0000269PubMed:18438418}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0008408	3'-5' exonuclease activity
GO:0019843	rRNA binding
GO:0043022	ribosome binding
GO:0046872	metal ion binding
GO:0071207	histone pre-mRNA stem-loop binding