InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc9a4

Summary

InnateDB Protein

IDBP-148801.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc9a4

Protein Name

solute carrier family 9 (sodium/hydrogen exchanger), member 4

Synonyms

AW990558; D730009J23Rik; NHE4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027233

InnateDB Gene

IDBG-148799 (Slc9a4)

Protein Structure

UniProt Annotation

Function

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange (By similarity). In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation. {ECO:0000250, ECO:0000269PubMed:12493726, ECO:0000269PubMed:15684419}.

Subcellular Localization

Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic granule membrane; Multi-pass membrane protein. Note=Found in zymogen granule membranes.

Disease Associations

Tissue Specificity

Expressed in kidney. Expressed in uterus and endometrial epithelial cells. Expressed in the inner segments of inner medullary collecting ducts (IMCD) in kidney. {ECO:0000269PubMed:9691122}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015299	solute:proton antiporter activity
GO:0015385	sodium:proton antiporter activity

Biological Process

GO:0001696	gastric acid secretion
GO:0002064	epithelial cell development
GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0006885	regulation of pH
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:1902600	hydrogen ion transmembrane transport