InnateDB Protein
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IDBP-14888.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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COPS7A
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Protein Name
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COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000229251
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InnateDB Gene
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IDBG-14886 (COPS7A)
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Protein Structure
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Function |
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269PubMed:11285227, ECO:0000269PubMed:11337588, ECO:0000269PubMed:12628923, ECO:0000269PubMed:12732143, ECO:0000269PubMed:9535219}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:9535219}. Nucleus {ECO:0000269PubMed:9535219}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed at high level in brain, heart and skeletal muscle. {ECO:0000269PubMed:12020345}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
81
[view]
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Protein-Protein |
79
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000717
Proteasome component (PCI) domain
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PFAM |
PF01399
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PRINTS |
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PIRSF |
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SMART |
SM00088
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBW8
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PhosphoSite |
PhosphoSite-Q9UBW8
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TrEMBL |
F5H7C6
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UniProt Splice Variant |
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Entrez Gene |
50813
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UniGene |
Hs.624025
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RefSeq |
NP_057403
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HUGO |
HGNC:16758
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OMIM |
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CCDS |
CCDS8558
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HPRD |
16736
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IMGT |
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EMBL |
AB014764
AB033603
AC125494
AF193844
AF210052
AK001318
AK021721
AK022488
AK292621
BC011789
CH471116
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GenPept |
AAF04307
AAF19205
AAH11789
BAA85390
BAA91620
BAB14052
BAB87805
BAF85310
BAG51042
EAW88745
EAW88747
EAW88748
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