InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bves

Summary

InnateDB Protein

IDBP-148898.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bves

Protein Name

blood vessel epicardial substance

Synonyms

mBVES; Pop1; Popdc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093382

InnateDB Gene

IDBG-148896 (Bves)

Protein Structure

UniProt Annotation

Function

Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3- mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. {ECO:0000269PubMed:11839816, ECO:0000269PubMed:16188940, ECO:0000269PubMed:18541910, ECO:0000269PubMed:20057356}.

Subcellular Localization

Lateral cell membrane. Cell junction, tight junction. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Detected at cell-cell contact but never observed at the free surface of epithelial cells (By similarity). Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in epithelial cells, skeletal muscle, heart and intestinal smooth muscle (at protein level). Expressed in fetal and adult heart and skeletal muscle. {ECO:0000269PubMed:10882522, ECO:0000269PubMed:11839816, ECO:0000269PubMed:16188940, ECO:0000269PubMed:18541910}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0030552	cAMP binding

Biological Process

GO:0001921	positive regulation of receptor recycling
GO:0002027	regulation of heart rate
GO:0002244	hematopoietic progenitor cell differentiation
GO:0008360	regulation of cell shape
GO:0016192	vesicle-mediated transport
GO:0032314	regulation of Rac GTPase activity
GO:0034446	substrate adhesion-dependent cell spreading
GO:0040017	positive regulation of locomotion
GO:0042391	regulation of membrane potential
GO:0043088	regulation of Cdc42 GTPase activity
GO:0060931	sinoatrial node cell development
GO:0090136	epithelial cell-cell adhesion

Cellular Component

GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016328	lateral plasma membrane

Protein Structure and Domains

PDB ID

MGI:1346013

InterPro

IPR006916 Popeye protein
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF04831

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ES83

PhosphoSite

PhosphoSite-Q9ES83

TrEMBL

UniProt Splice Variant

Entrez Gene

23828

UniGene

RefSeq

NP_077247

MGI ID

MGI Symbol

Bves

OMIM

CCDS

CCDS23828

HPRD

IMGT

EMBL

AF124510 AF204174 AK046765 BC132018 BC132044

GenPept

AAG23407 AAI32019 AAI32045 BAC32859