InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nanos2

Summary

InnateDB Protein

IDBP-148979.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nanos2

Protein Name

nanos homolog 2 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069765

InnateDB Gene

IDBG-148977 (Nanos2)

Protein Structure

UniProt Annotation

Function

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state. {ECO:0000269PubMed:12947200, ECO:0000269PubMed:17138666, ECO:0000269PubMed:18281459, ECO:0000269PubMed:19745153, ECO:0000269PubMed:20133598}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20133598}. Cytoplasm, P-body {ECO:0000269PubMed:20133598}. Cytoplasm, perinuclear region {ECO:0000250}. Note=More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis (By similarity). Localizes at P-bodies during gonocyte development. {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in male germ cells. Expressed in self-renewing spermatogonial stem cells and developing gonads. {ECO:0000269PubMed:12947200, ECO:0000269PubMed:19745153}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006402	mRNA catabolic process
GO:0006417	regulation of translation
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030718	germ-line stem cell maintenance
GO:0045835	negative regulation of meiosis