Version 5.4
| Mus musculus Protein: Tns3 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-148982.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Tns3 | ||||||||
| Protein Name | tensin 3 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000020695 | ||||||||
| InnateDB Gene | IDBG-148980 (Tns3) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration (By similarity). May be involved in cell migration and bone development. {ECO:0000250, ECO:0000269PubMed:15733665}. | ||||||||
| Subcellular Localization | Cell junction, focal adhesion {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in brain, heart, lung, liver, spleen, kidney, stomach, small intestine, skeletal muscle, skin, thymus, testis, uterus, placenta, aorta and trachea. {ECO:0000269PubMed:15733665}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2443012 | ||||||||
| InterPro |
IPR000008
C2 domain IPR000387 Protein-tyrosine/Dual specificity phosphatase IPR000980 SH2 domain IPR003595 Protein-tyrosine phosphatase, catalytic IPR006020 PTB/PI domain IPR013625 Tensin phosphotyrosine-binding domain IPR014020 Tensin phosphatase, C2 domain IPR029021 Protein-tyrosine phosphatase-like IPR029023 Tensin phosphatase, lipid phosphatase domain |
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| PFAM |
PF00168
PF00017 PF14633 PF00640 PF14719 PF08416 PF10409 |
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| PRINTS |
PR00360
PR00401 |
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| PIRSF | |||||||||
| SMART |
SM00239
SM00252 SM00404 SM00462 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q5SSZ5 | ||||||||
| PhosphoSite | PhosphoSite-Q5SSZ5 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 319939 | ||||||||
| UniGene | Mm.337820 | ||||||||
| RefSeq | NP_001077056 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Tns3 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS36109 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK089717 AK158101 AL603845 AL662881 | ||||||||
| GenPept | BAC40948 BAE34356 CAI24138 CAI25142 | ||||||||