Version 5.4
| Mus musculus Protein: Dennd3 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-148987.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Dennd3 | ||||||||
| Protein Name | DENN/MADD domain containing 3 | ||||||||
| Synonyms | AI447457; E030003N15Rik; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000046774 | ||||||||
| InnateDB Gene | IDBG-148985 (Dennd3) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. {ECO:0000269PubMed:21718402}. | ||||||||
| Subcellular Localization | |||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2146009 | ||||||||
| InterPro |
IPR001194
DENN domain IPR001680 WD40 repeat IPR005112 dDENN domain IPR005113 uDENN domain IPR017986 WD40-repeat-containing domain |
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| PFAM |
PF02141
PF00400 PF03455 PF03456 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00799
SM00320 SM00801 SM00800 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | A2RT67 | ||||||||
| PhosphoSite | PhosphoSite-A2RT67 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 105841 | ||||||||
| UniGene | Mm.322557 | ||||||||
| RefSeq | NP_001074535 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Dennd3 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS37100 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK053114 AK173046 BC132389 BC137791 | ||||||||
| GenPept | AAI32390 AAI37792 BAC35269 BAD32324 | ||||||||