InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mypop

Summary

InnateDB Protein

IDBP-149006.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mypop

Protein Name

Myb-related transcription factor, partner of profilin

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058718

InnateDB Gene

IDBG-149004 (Mypop)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity. {ECO:0000269PubMed:15615774}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15615774}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in brain, liver and testis. Moderate expression in heart, lung and skeletal muscle. Low expression in spleen and kidney. {ECO:0000269PubMed:15615774}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter