InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnab1

Summary

InnateDB Protein

IDBP-149073.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnab1

Protein Name

potassium voltage-gated channel, shaker-related subfamily, beta member 1

Synonyms

Akr8a8; Kvbeta1.1; mKv(beta)1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047480

InnateDB Gene

IDBG-149071 (Kcnab1)

Protein Structure

UniProt Annotation

Function

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alter the functional properties of Kv1.1 and Kv1.4.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly expressed in brain. No expression found in heart, skeletal muscle or kidney. In the late embryonic and early neonatal brain, highly expressed in hippocampus, cerebral cortex, caudate putamen, colliculus and cerebellum. {ECO:0000269PubMed:9468385}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding

Biological Process

GO:0006813	potassium ion transport
GO:0007611	learning or memory
GO:0071805	potassium ion transmembrane transport
GO:1901016	regulation of potassium ion transmembrane transporter activity

Cellular Component

GO:0005737	cytoplasm
GO:0008076	voltage-gated potassium channel complex

Protein Structure and Domains

PDB ID

MGI:109155

InterPro

IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related
IPR005400 Potassium channel, voltage-dependent, beta subunit, KCNAB1
IPR005402 Potassium channel, voltage-dependent, beta subunit, KCNAB3
IPR005983 Potassium channel, voltage-dependent, beta subunit, KCNAB
IPR023210 NADP-dependent oxidoreductase domain

PFAM

PF00248

PRINTS

PR01577
PR01578
PR01580

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P63143