InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kng1

Summary

InnateDB Protein

IDBP-149121.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kng1

Protein Name

kininogen 1

Synonyms

Kng;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040485

InnateDB Gene

IDBG-149119 (Kng1)

Protein Structure

UniProt Annotation

Function

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.