InnateDB Protein
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IDBP-149125.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Kng1
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Protein Name
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kininogen 1
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Synonyms
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Kng;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000023589
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InnateDB Gene
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IDBG-149119 (Kng1)
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Protein Structure
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Function |
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted, extracellular space.
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Disease Associations |
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Tissue Specificity |
Plasma.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004869
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cysteine-type endopeptidase inhibitor activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1097705
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InterPro |
IPR000010
Proteinase inhibitor I25, cystatin
IPR002395
HMW kininogen
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PFAM |
PF00031
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PRINTS |
PR00334
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PIRSF |
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SMART |
SM00043
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TIGRFAMs |
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Modification |
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SwissProt |
O08677
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PhosphoSite |
PhosphoSite-O08677
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TrEMBL |
D3Z2B2
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UniProt Splice Variant |
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Entrez Gene |
16644
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UniGene |
Mm.2160
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RefSeq |
NP_001095881
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MGI ID |
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MGI Symbol |
Kng1
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OMIM |
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CCDS |
CCDS49804
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HPRD |
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IMGT |
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EMBL |
AC154540
AK005547
AY462058
AY660571
BC018158
BC108936
D84415
D84435
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GenPept |
AAH18158
AAI08937
AAR88632
AAT70087
BAA19742
BAA19743
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