InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pou3f3

Summary

InnateDB Protein

IDBP-149166.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pou3f3

Protein Name

POU domain, class 3, transcription factor 3

Synonyms

Brn-1; Brn1; Otf8; Skin1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052088

InnateDB Gene

IDBG-149164 (Pou3f3)

Protein Structure

UniProt Annotation

Function

Transcription factor that acts synergistically with SOX11 and SOX4 (By similarity). Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3'). {ECO:0000250, ECO:0000269PubMed:10473120, ECO:0000269PubMed:12130536, ECO:0000269PubMed:19527706}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000255PROSITE-ProRule:PRU00530, ECO:0000269PubMed:10473120}.

Disease Associations

Tissue Specificity

Brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0071837	HMG box domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001822	kidney development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021869	forebrain ventricular zone progenitor cell division
GO:0043066	negative regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0072218	metanephric ascending thin limb development
GO:0072227	metanephric macula densa development
GO:0072233	metanephric thick ascending limb development
GO:0072236	metanephric loop of Henle development
GO:0072240	metanephric DCT cell differentiation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:102564

InterPro

IPR000327 POU-specific
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR013847 POU domain
IPR016362 Transcription factor, homeobox/POU

PFAM

PF00157
PF00046
PF13413

PRINTS

PR00028

PIRSF

PIRSF002629

SMART

SM00352
SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References