InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Znrf2

Summary

InnateDB Protein

IDBP-149258.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Znrf2

Protein Name

zinc and ring finger 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078795

InnateDB Gene

IDBG-149256 (Znrf2)

Protein Structure

UniProt Annotation

Function

May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). {ECO:0000250}.

Subcellular Localization

Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Present in presynaptic plasma membranes in neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed primarily in the nervous system. Expression is more intense in the granular cell layer of hippocampus, Purkinje cell layer of the cerebellum and the granular cell layer of the olfactory bulb. Detected in sensory neurons but not expressed in sympatic or enteric neurons. Expressed in testis, adipose tissue, columnar epithelial cells of the gut. {ECO:0000269PubMed:14561866}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0008150	biological_process
GO:0016567	protein ubiquitination

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0030054	cell junction
GO:0030659	cytoplasmic vesicle membrane
GO:0042734	presynaptic membrane
GO:0043234	protein complex