Version 5.4
| Mus musculus Protein: Ptp4a3 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-149287.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Ptp4a3 | ||||||||
| Protein Name | protein tyrosine phosphatase 4a3 | ||||||||
| Synonyms | AV088979; pPtp4a3; Prl-3; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000060956 | ||||||||
| InnateDB Gene | IDBG-149285 (Ptp4a3) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. {ECO:0000269PubMed:15161639}. | ||||||||
| Subcellular Localization | Cell membrane. Early endosome. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Present in the small intestine, where it is located in the differentiated epithelial cells of the villus but not in the proliferating crypt cells (at protein level). Expressed in heart and skeletal muscle, and at lower levels in lung, spleen and testis. {ECO:0000269PubMed:15161639, ECO:0000269PubMed:9514946}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1277098 | ||||||||
| InterPro |
IPR000242
Protein-tyrosine phosphatase, receptor/non-receptor type IPR000340 Dual specificity phosphatase, catalytic domain IPR000387 Protein-tyrosine/Dual specificity phosphatase IPR003595 Protein-tyrosine phosphatase, catalytic IPR029021 Protein-tyrosine phosphatase-like |
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| PFAM |
PF00102
PF00782 |
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| PRINTS |
PR00700
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| PIRSF | |||||||||
| SMART |
SM00194
SM00404 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9D658 | ||||||||
| PhosphoSite | PhosphoSite-Q9D658 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 19245 | ||||||||
| UniGene | Mm.390807 | ||||||||
| RefSeq | NP_033001 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Ptp4a3 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS27519 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF035645 AK003954 AK014601 AK143702 AK172192 BC027445 BC066043 | ||||||||
| GenPept | AAC15875 AAH27445 AAH66043 BAB23091 BAB29456 BAE25506 BAE42875 | ||||||||