InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Meiob

Summary

InnateDB Protein

IDBP-149335.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Meiob

Protein Name

RIKEN cDNA 4930528F23 gene

Synonyms

4930528F23Rik; MLZ-675;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024972

InnateDB Gene

IDBG-149331 (Meiob)

Protein Structure

UniProt Annotation

Function

Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro. {ECO:0000269PubMed:20339383, ECO:0000269PubMed:24068956, ECO:0000269PubMed:24240703}.

Subcellular Localization

Cytoplasm. Nucleus. Chromosome. Note=Co- localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22.

Disease Associations

Tissue Specificity

Sprecifically expressed in early meiotic germ cells: in adult and fetal tissues, detected in fetal ovary, postnatal testis and liver. In the ovary, expression starts at 12.5 dpc, reaches a maximum at 15.5 dpc and decreases to become undetectable in post natal life. In testis, expression starts at 10 days post partum (dpp), reaches a maximum at 20 dpp and is maintained throughout adult life. {ECO:0000269PubMed:24068956, ECO:0000269PubMed:24240703}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0000724	double-strand break repair via homologous recombination
GO:0000738	DNA catabolic process, exonucleolytic
GO:0007129	synapsis
GO:0007140	male meiosis
GO:0007141	male meiosis I
GO:0007144	female meiosis I
GO:0009566	fertilization