InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hagh

Summary

InnateDB Protein

IDBP-149451.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hagh

Protein Name

hydroxyacyl glutathione hydrolase

Synonyms

BC019817; Glo-2; Glo2; Rsp29;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024974

InnateDB Gene

IDBG-149449 (Hagh)

Protein Structure

UniProt Annotation

Function

Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid.

Subcellular Localization

Isoform 1: Mitochondrion matrix {ECO:0000250}.Isoform 2: Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004416	hydroxyacylglutathione hydrolase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity

Biological Process

GO:0006750

glutathione biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:95745

InterPro

IPR001279 Beta-lactamase-like
IPR017782 Hydroxyacylglutathione hydrolase

PFAM

PF00753

PRINTS

PIRSF

PIRSF005457

SMART

SM00849

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99KB8

PhosphoSite

PhosphoSite-Q99KB8

TrEMBL

E9Q2H8

UniProt Splice Variant

Entrez Gene

14651

UniGene

Mm.43784

RefSeq

NP_001153098

MGI ID

MGI Symbol

Hagh

OMIM

CCDS

CCDS50021

HPRD

IMGT

EMBL

AC166102 AK147022 AK150557 AK151231 AK152742 AK165777 BC004749 BC019817

GenPept

AAH04749 AAH19817 BAE27615 BAE29657 BAE30223 BAE31462 BAE38377