InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccnl1

Summary

InnateDB Protein

IDBP-149497.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccnl1

Protein Name

cyclin L1

Synonyms

2610030E23Rik; ania-6a; AU018493; Ccnl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029416

InnateDB Gene

IDBG-149495 (Ccnl1)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor p21 (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 1: Nucleus speckle. Note=More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.Isoform 2: Nucleus. Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006396	RNA processing