InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fhl2

Summary

InnateDB Protein

IDBP-149556.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fhl2

Protein Name

four and a half LIM domains 2

Synonyms

FHL-2; SLIM-3; SLIM3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008280

InnateDB Gene

IDBG-149554 (Fhl2)

Protein Structure

UniProt Annotation

Function

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart but also detectable in brain and skeletal muscle. {ECO:0000269PubMed:10906474}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	68 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0042802	identical protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0009725	response to hormone
GO:0043066	negative regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055014	atrial cardiac muscle cell development
GO:0055015	ventricular cardiac muscle cell development
GO:0060347	heart trabecula formation