InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crhr2

Summary

InnateDB Protein

IDBP-149595.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Crhr2

Protein Name

corticotropin releasing hormone receptor 2

Synonyms

CRF-R2; Crfr2; CRFR2alpha; CRFR2beta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003568

InnateDB Gene

IDBG-149593 (Crhr2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0015056	corticotrophin-releasing factor receptor activity

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0016525	negative regulation of angiogenesis
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0071376	cellular response to corticotropin-releasing hormone stimulus

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:894312

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR002001 GPCR, family 2, diuretic hormone receptor
IPR003051 GPCR, family 2, corticotropin releasing factor receptor
IPR003053 GPCR, family 2, corticotropin releasing factor receptor, type 2
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR01127
PR01279
PR01281

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt