Version 5.4
Mus musculus Protein: Crhr2
Summary
InnateDB Protein IDBP-149597.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Crhr2
Protein Name corticotropin releasing hormone receptor 2
Synonyms CRF-R2; Crfr2; CRFR2alpha; CRFR2beta;
Species Mus musculus
Ensembl Protein ENSMUSP00000093586
InnateDB Gene IDBG-149593 (Crhr2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0015056 corticotrophin-releasing factor receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0016525 negative regulation of angiogenesis
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0071376 cellular response to corticotropin-releasing hormone stimulus
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0009986 cell surface
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:894312
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR003051 GPCR, family 2, corticotropin releasing factor receptor
IPR003053 GPCR, family 2, corticotropin releasing factor receptor, type 2
PFAM PF02793
PRINTS PR01279
PR01281
PIRSF
SMART SM00008
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5ERJ2
UniProt Splice Variant
Entrez Gene 12922
UniGene Mm.236081
RefSeq
MGI ID
MGI Symbol Crhr2
OMIM
CCDS
HPRD
IMGT
EMBL AC079243 AY753668
GenPept AAU94301

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca