InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chsy3

Summary

InnateDB Protein

IDBP-149678.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chsy3

Protein Name

chondroitin sulfate synthase 3

Synonyms

4833446K15Rik; AI662215;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079546

InnateDB Gene

IDBG-149676 (Chsy3)

Protein Structure

UniProt Annotation

Function

Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1 (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0016757	transferase activity, transferring glycosyl groups
GO:0016758	transferase activity, transferring hexosyl groups
GO:0046872	metal ion binding
GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity