Version 5.4
Mus musculus Protein: Eml2
Summary
InnateDB Protein IDBP-149728.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eml2
Protein Name echinoderm microtubule associated protein like 2
Synonyms 1600029N02Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000037654
InnateDB Gene IDBG-149726 (Eml2)
Protein Structure
UniProt Annotation
Function Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Colocalizes with the microtubule cytoskeleton. Colocalizes with the mitotic spindle (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008022 protein C-terminus binding
GO:0015631 tubulin binding
Biological Process
GO:0008150 biological_process
GO:0010968 regulation of microtubule nucleation
GO:0031115 negative regulation of microtubule polymerization
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0043231 intracellular membrane-bounded organelle
GO:0072686 mitotic spindle
Protein Structure and Domains
PDB ID MGI:1919455
InterPro IPR001680 WD40 repeat
IPR005108 HELP
IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PF03451
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TNG5
PhosphoSite PhosphoSite-Q7TNG5
TrEMBL
UniProt Splice Variant
Entrez Gene 72205
UniGene Mm.487810
RefSeq NP_082429
MGI ID
MGI Symbol Eml2
OMIM
CCDS CCDS52055
HPRD
IMGT
EMBL AK005562 BC055476
GenPept AAH55476 BAB24122

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca