InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: 1500015O10Rik

Summary

InnateDB Protein

IDBP-149734.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

1500015O10Rik

Protein Name

RIKEN cDNA 1500015O10 gene

Synonyms

Ecrg4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027217

InnateDB Gene

IDBG-149732 (1500015O10Rik)

Protein Structure

UniProt Annotation

Function

Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation. {ECO:0000269PubMed:20404145}.

Subcellular Localization

Secreted {ECO:0000269PubMed:20404145}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the intermediate lobe of pituitary, glomerular layer of adrenal cortex, choroid plexus and atrioventricular node of the heart. {ECO:0000269PubMed:17284679}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0008054	cyclin catabolic process
GO:0070314	G1 to G0 transition
GO:0090398	cellular senescence

Cellular Component

GO:0005615	extracellular space
GO:0030133	transport vesicle

Protein Structure and Domains

PDB ID

MGI:1926146

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99LS0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

78896

UniGene

RefSeq

NP_077245

MGI ID

MGI Symbol

1500015O10Rik

OMIM

CCDS

CCDS14925

HPRD

IMGT

EMBL

AC159092 AK018770 AK049805 BC002254

GenPept

AAH02254 BAB31398 BAE20668