InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Iigp1

Summary

InnateDB Protein

IDBP-149757.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Iigp1

Protein Name

interferon inducible GTPase 1

Synonyms

2900074L10Rik; AI046432; AW111922; Ifgga1; Iigp; Irga6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032473

InnateDB Gene

IDBG-149755 (Iigp1)

Protein Structure

UniProt Annotation

Function

GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction. {ECO:0000269PubMed:11907101, ECO:0000269PubMed:12732635, ECO:0000269PubMed:16304607, ECO:0000269PubMed:19242543}.

Subcellular Localization

Cytoplasm. Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Parasitophorous vacuole membrane. Note=Localizes to the bacterial inclusions formed following C.trachomatis infection. Accumulates in a GTP-bound form on the parasitophorous vacuole membranes formed following T.gondii infection but exists in a GDP-bound form in uninfected cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0019003	GDP binding
GO:0042802	identical protein binding

Biological Process

GO:0006184	GTP catabolic process
GO:0010506	regulation of autophagy
GO:0019221	cytokine-mediated signaling pathway
GO:0035458	cellular response to interferon-beta
GO:0042832	defense response to protozoan
GO:0045087	innate immune response
GO:0050829	defense response to Gram-negative bacterium

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0020005	symbiont-containing vacuole membrane
GO:0031965	nuclear membrane
GO:0032580	Golgi cisterna membrane