InnateDB Protein
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IDBP-149791.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Akap2
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Protein Name
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A kinase (PRKA) anchor protein 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099966
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InnateDB Gene
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IDBG-149775 (Akap2)
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Protein Structure
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Function |
Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Highly expressed in lung and weakly in thymus and cerebellum. Little or no expression in liver, heart and cerebral cortex. All isoforms are expressed in lung, but KL2A and KL2B isoforms are the principal isoforms in cerebellum.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1306795
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InterPro |
IPR018459
RII binding domain
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PFAM |
PF10522
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O54931
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PhosphoSite |
PhosphoSite-O54931
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TrEMBL |
A2APJ1
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UniProt Splice Variant |
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Entrez Gene |
11641
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UniGene |
Mm.489125
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RefSeq |
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MGI ID |
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MGI Symbol |
Akap2
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OMIM |
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CCDS |
CCDS18205
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HPRD |
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IMGT |
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EMBL |
AF033274
AF033275
AF033276
AK077020
AK147420
AL840629
AL954706
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GenPept |
AAC02206
AAC02207
AAC02208
BAC36571
BAE27901
CAM21291
CAM21292
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