Version 5.4
Mus musculus Protein: Akap2
Summary
InnateDB Protein IDBP-149797.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akap2
Protein Name A kinase (PRKA) anchor protein 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000095672
InnateDB Gene IDBG-149775 (Akap2)
Protein Structure
UniProt Annotation
Function Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP.
Subcellular Localization
Disease Associations
Tissue Specificity Highly expressed in lung and weakly in thymus and cerebellum. Little or no expression in liver, heart and cerebral cortex. All isoforms are expressed in lung, but KL2A and KL2B isoforms are the principal isoforms in cerebellum.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
Protein Structure and Domains
PDB ID MGI:1306795
InterPro IPR018459 RII binding domain
PFAM PF10522
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O54931
PhosphoSite PhosphoSite-O54931
TrEMBL A2APJ1
UniProt Splice Variant
Entrez Gene 11641
UniGene Mm.489125
RefSeq
MGI ID
MGI Symbol Akap2
OMIM
CCDS CCDS18203
HPRD
IMGT
EMBL AF033274 AF033275 AF033276 AK077020 AK147420 AL840629 AL954706
GenPept AAC02206 AAC02207 AAC02208 BAC36571 BAE27901 CAM21291 CAM21292

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca