Version 5.4
Mus musculus Protein: Dctn4
Summary
InnateDB Protein IDBP-149860.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dctn4
Protein Name dynactin 4
Synonyms 1110001K06Rik; 4930547K17Rik; C130039E17Rik; p62;
Species Mus musculus
Ensembl Protein ENSMUSP00000025505
InnateDB Gene IDBG-149858 (Dctn4)
Protein Structure
UniProt Annotation
Function Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000269PubMed:19109891}. Note=Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (By similarity). In skeletal muscles, costamere localization requires the presence of ANK2. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0047485 protein N-terminus binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005813 centrosome
GO:0005869 dynactin complex
GO:0030017 sarcomere
Protein Structure and Domains
PDB ID MGI:1914915
InterPro IPR008603 Dynactin p62
PFAM PF05502
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CBY8
PhosphoSite PhosphoSite-Q8CBY8
TrEMBL Q9CRP9
UniProt Splice Variant
Entrez Gene 67665
UniGene Mm.456202
RefSeq NP_080578
MGI ID
MGI Symbol Dctn4
OMIM
CCDS CCDS37832
HPRD
IMGT
EMBL AK016059 AK019382 AK034292 AK160813 AK163240 AK168484 BC006677 BC034725
GenPept AAH06677 AAH34725 BAB30095 BAB31691 BAC28661 BAE36028 BAE37250 BAE40371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca