InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ONECUT3

Summary

InnateDB Protein

IDBP-14988.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ONECUT3

Protein Name

one cut homeobox 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000371786

InnateDB Gene

IDBG-14986 (ONECUT3)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000255PROSITE-ProRule:PRU00374}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0031018	endocrine pancreas development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter