InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Inmt

Summary

InnateDB Protein

IDBP-149895.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Inmt

Protein Name

indolethylamine N-methyltransferase

Synonyms

Temt;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003569

InnateDB Gene

IDBG-149893 (Inmt)

Protein Structure

UniProt Annotation

Function

Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n- propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds. {ECO:0000250, ECO:0000269PubMed:3350800}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:3350800}.

Disease Associations

Tissue Specificity

Detected in lung and liver (at protein level). {ECO:0000269PubMed:3350800}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004790	thioether S-methyltransferase activity
GO:0008168	methyltransferase activity
GO:0030748	amine N-methyltransferase activity