InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Barx1

Summary

InnateDB Protein

IDBP-149911.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Barx1

Protein Name

BarH-like homeobox 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021813

InnateDB Gene

IDBG-149909 (Barx1)

Protein Structure

UniProt Annotation

Function

Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity. Binds to a regulatory module of the NCAM promoter. {ECO:0000269PubMed:15809042, ECO:0000269PubMed:17855428}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed predominantly in the facial primordia, developing stomach, and proximal limbs.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007267	cell-cell signaling
GO:0009888	tissue development
GO:0009952	anterior/posterior pattern specification
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030855	epithelial cell differentiation
GO:0048513	organ development
GO:0048536	spleen development
GO:0048856	anatomical structure development
GO:0055123	digestive system development