InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shox2

Summary

InnateDB Protein

IDBP-149930.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shox2

Protein Name

short stature homeobox 2

Synonyms

6330543G17Rik; OG12; Og12x; Prx3; SHOT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029422

InnateDB Gene

IDBG-149928 (Shox2)

Protein Structure

UniProt Annotation

Function

May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. May also have a role in heart development.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in striated muscle followed by liver, kidney, testis, brain, heart, lung and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002062	chondrocyte differentiation
GO:0002063	chondrocyte development
GO:0003170	heart valve development
GO:0003209	cardiac atrium morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0030326	embryonic limb morphogenesis
GO:0032330	regulation of chondrocyte differentiation
GO:0035115	embryonic forelimb morphogenesis
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048557	embryonic digestive tract morphogenesis
GO:0048598	embryonic morphogenesis
GO:0048743	positive regulation of skeletal muscle fiber development
GO:0050772	positive regulation of axonogenesis
GO:0060272	embryonic skeletal joint morphogenesis
GO:0060351	cartilage development involved in endochondral bone morphogenesis
GO:0060415	muscle tissue morphogenesis
GO:2000172	regulation of branching morphogenesis of a nerve