Version 5.4
Mus musculus Protein: Surf6
Summary
InnateDB Protein IDBP-149948.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Surf6
Protein Name surfeit gene 6
Synonyms D2Wsu129e; Surf-6;
Species Mus musculus
Ensembl Protein ENSMUSP00000048457
InnateDB Gene IDBG-149946 (Surf6)
Protein Structure
UniProt Annotation
Function Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly. {ECO:0000269PubMed:9548374}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000269PubMed:8639267, ECO:0000269PubMed:9548374}. Note=Granular component of the nucleolus.
Disease Associations
Tissue Specificity Expressed in all tissues tested, including heart, brain, spleen, lung, liver, muscle, kidney and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0042254 ribosome biogenesis
GO:0042255 ribosome assembly
Cellular Component
GO:0001652 granular component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID MGI:98447
InterPro IPR029190 Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain
PFAM PF04935
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70279
PhosphoSite PhosphoSite-P70279
TrEMBL Q3V1X4
UniProt Splice Variant
Entrez Gene 20935
UniGene Mm.481944
RefSeq NP_033324
MGI ID
MGI Symbol Surf6
OMIM
CCDS CCDS15812
HPRD
IMGT
EMBL AK043984 AK075636 AK132194 BC026514 BC037634 CH466542 X92842
GenPept AAH26514 AAH37634 BAC31725 BAC35872 BAE21025 CAA63428 EDL08333

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca