InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpn1

Summary

InnateDB Protein

IDBP-149957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpn1

Protein Name

GPN-loop GTPase 1

Synonyms

2410004J02Rik; AI449615; MBDIN; NTPBP; Xab1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000076217

InnateDB Gene

IDBG-149955 (Gpn1)

Protein Structure

UniProt Annotation

Function

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0008150	biological_process
GO:0008152	metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1921504

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR003495 CobW/HypB/UreG domain
IPR003593 AAA+ ATPase domain
IPR004130 Uncharacterised protein family, ATP binding
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF02492
PF03029

PRINTS

PR00315

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt