Version 5.4
Mus musculus Protein: Ids
Summary
InnateDB Protein IDBP-149989.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ids
Protein Name iduronate 2-sulfatase
Synonyms AW214631;
Species Mus musculus
Ensembl Protein ENSMUSP00000099046
InnateDB Gene IDBG-149987 (Ids)
Protein Structure
UniProt Annotation
Function Required for the lysosomal degradation of heparan sulfate and dermatan sulfate. {ECO:0000269PubMed:15149955}.
Subcellular Localization Lysosome.
Disease Associations
Tissue Specificity Found to be expressed in alpha and beta pancreatic cells. {ECO:0000269PubMed:15149955}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004423 iduronate-2-sulfatase activity
GO:0005515 protein binding
GO:0008484 sulfuric ester hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005764 lysosome
Protein Structure and Domains
PDB ID MGI:96417
InterPro IPR000917 Sulfatase
IPR017850 Alkaline-phosphatase-like, core domain
PFAM PF00884
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08890
PhosphoSite PhosphoSite-Q08890
TrEMBL Q8CJ15
UniProt Splice Variant
Entrez Gene 15931
UniGene Mm.409144
RefSeq NP_034628
MGI ID
MGI Symbol Ids
OMIM
CCDS CCDS40996
HPRD
IMGT
EMBL AF538870 AK166178 BN000750 BX294168 L07921
GenPept AAA37880 AAN16453 BAE38612 CAI84996 CAM20128

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca