Version 5.4
Mus musculus Protein: Med22
Summary
InnateDB Protein IDBP-149994.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Med22
Protein Name mediator complex subunit 22
Synonyms AW212655; AW558812; Surf-5; Surf5;
Species Mus musculus
Ensembl Protein ENSMUSP00000099963
InnateDB Gene IDBG-149992 (Med22)
Protein Structure
UniProt Annotation
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
Cellular Component
GO:0005654 nucleoplasm
GO:0016592 mediator complex
Protein Structure and Domains
PDB ID MGI:98446
InterPro IPR009332 Mediator complex, subunit Med22
PFAM PF06179
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62276
PhosphoSite PhosphoSite-Q62276
TrEMBL
UniProt Splice Variant
Entrez Gene 20933
UniGene Mm.397932
RefSeq NP_035643
MGI ID
MGI Symbol Med22
OMIM
CCDS CCDS15814
HPRD
IMGT
EMBL AK144744 AK161053 AK166250 AK166474 AL773563 BC018225 X85169
GenPept AAH18225 BAE26044 BAE36173 BAE38661 BAE38795 CAA59453 CAM23699 CAM23700

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca